Fa'amatalaga Puupuu:
Numera CAS:51322-75-9
fua mole:C9H8ClN5S
mamafa mole:253.71
Fa'atonuga vaila'au:
| Fa'amatalaga Autu | |
| Igoa o oloa | Tizanidine |
| Vasega | Vasega Pharma |
| Fa'aaliga | Pa'u Pa'epa'e |
| Su'ega | 99% |
| Ola fa'asa | 2 tausaga |
| afifiina | 25kg/tapa |
| Tulaga | Teu i le -20°C |
Otootoga
Tizanidine o se imidazoline lua nitrogen heterocyclic pentene derivative. O le fausaga e tutusa ma le clonidine. I le 1987, na muamua lisiina i Finelani e avea o se fatugalemu o le adrenalin α2 receptor agonist. I le taimi nei, o loʻo faʻaaogaina e fai ma faʻamalosaga maso tutotonu i le falemaʻi. E mafai ona fa'aaogaina e togafitia ai maso tiga, pei ole ma'i o le puimanava o le ua ma le torticollis. E mafai fo'i ona fa'aoga e togafitia ai le tiga pe a mae'a le taotoga, e pei o le fa'ama'i o le tisiketi ma le gasegase o le suilapalapa. E sau mai le ankylosis o faʻafitauli o le neurological, e pei ole tele sclerosis, myelopathy masani, faʻalavelave faʻafuaseʻi ma isi.
Galuega
E faʻaaogaina e faʻaitiitia ai le faʻalavelave maso o le skeletal, maso spasm ma myotonia e mafua mai i le faiʻai ma le faʻamaʻi manuʻa, toto toto, encephalitis ma le tele sclerosis.
Pharmacology
E faʻaitiitia faʻaititia le tuʻuina atu o amino acids excitatory mai interneurons ma faʻalavelaveina le tele synaptic masini e fesoʻotaʻi ma maso overstrain. O lenei oloa e le afaina ai le felauaiga o le neuromuscular. E talia lelei. E aoga mo musele tiga tiga ma le ankylosis faaumiumi e afua mai i le taula'au ma le fai'ai. E mafai ona faʻaitiitia le teteʻe o gaioiga passive, faʻaitiitia le spasticity ma le clonus, ma faʻateleina le malosi o le gaioiga ofo.
Fa'aoga
Fa'ailoga Tizanidine, fa'amoemoe mo le fa'aogaina o se fa'ata'ita'iga fa'alotoifale mo le fa'atusatusaina o le Tizanidine e le GC- po'o le LC-mass spectrometry. Tizanidine e mafai ona faʻaaogaina togafitiga e avea ma SARS-CoV-2 main protease inhibitor.
Fa'aoga Fa'afoma'i
O le Tizanidine ose agonist fa'atotonugalemu adrenergic α2 e fa'aaogaina e togafitia ai fa'ama'i fa'ama'i o maso, pei ole tele sclerosis.
Faiga o gaioiga
O le Tizanidine o se fa'ata'ita'iga fa'amama maso fa'atotonugalemu o le clonidine lea e fa'atagaina mo le fa'aogaina e fa'aitiitia ai le fa'ama'i e feso'ota'i ma manu'a o le cerebral po'o le va'ai. O lona faiga o gaioiga mo le faʻaitiitia o le spasticity o loʻo faʻaalia ai le faʻalavelave presynaptic o neu afi i leα2-adrenergic receptor sites, faʻaitiitia le tuʻuina atu o amino acids excitatory ma faʻalavelaveina auala ceruleospinal faʻafaigofie, ma mafua ai le faʻaitiitia o le spasticity. Tizanidine e na'o se vaega itiiti o le antihypertensive action of clonidine, masalo ona o le gaioiga i se vaega filifilia o le clonidine.α2C-adrenoceptors, lea e foliga mai e nafa ma gaioiga faʻamaʻi ma antispasmodic o imidazolineα2-agonists(20).
