Fa'amatalaga Puupuu:
Numera CAS:55268-74-1
fua mole:C19H24N2O2
mamafa mole:312.41
Fa'atonuga vaila'au:
| Fa'amatalaga Autu | |
| Igoa o oloa | Praziquantel |
| Vasega | Vasega Pharma |
| Fa'aaliga | E pa'epa'e pe toetoe a pa'epa'e tioata tioata |
| Su'ega | 99% |
| Ola fa'asa | 2 tausaga |
| afifiina | 25kg/tapa |
| Uiga | E solu fua ile ethanol po'o le dichloromethane. Solu teisi i le vai |
| Tulaga | Faamauina i le mago, Teu i totonu o le pusaaisa, i lalo -20°C |
Fa'amatalaga
Praziquantel (PZQ) o se isoquinoline derivative ma le tele o gaioiga olaola o loʻo maua i le levo enantiomer. E leai se gaioiga a le faʻapotopotoga e faasaga i nematodes, ae e sili ona aoga i cestodes ma trematodes.
Pharmacology ma le faiga o gaioiga
O le Praziquantel o se pyrazinoquinoline faʻapipiʻi muamua na atiaʻe mo togafitiga o le schistosomiasis ae ua maua o loʻo i ai le tele o alaleo o gaioiga anthelminthic. O le Praziquantel o se tagata fa'atauva'a ae o le R (+) enantiomer e na'o le nafa ma ana gaioiga fa'atosina. E malosi e tetee atu i trematodes (o ituaiga uma o Schistosoma pathogenic i le tagata, Paragonimus westermani, ma Clonorchis sinensis) ma cestodes (Taenia saginata, Taenia solium, Hymenolepis nana ma Diphyllobothrium latum) .
Ole faiga ole gaioiga ole praziquantel e le o iloa lelei. E vave ona tagofia e Schistosomes le fualaau faasaina. O le fa'aaogaina o fualaau fa'asaina e vave ona soso'o ai ma le fa'ateleina o le gaioioiga maso e fa'asolo atu i le tetanic ma le vacuolization o le parasite tegument.
O a'afiaga maso o le vaila'au o lo'o fa'apea e nafa ma le fa'aliliuina atu o parasite mai veins mesenteric i le ate i vivo. Ae ui i lea, ua fa'aalia le suiga ole ate ile tele ole schistososomicides ua iloa ma e ono le maua ai ni fa'amatalaga patino ole faiga ole gaioiga ole vaila'au. O suʻesuʻega faʻataʻitaʻiga lata mai ua fautua mai ai o aʻafiaga antischistosomal o le vailaʻau e fesoʻotaʻi ma lona aʻafiaga i le tegument nai lo le musculature.
O le isi aʻafiaga faʻafomaʻi o le vailaʻau e aofia ai le faʻateleina o le membrane permeability i cations, aemaise lava le calcium.
Ae ui i lea, o le matafaioi o lenei aafiaga i le meatotino anthelminthic o le fualaau faasaina e le o iloa.
Fa'atatauga
O se ituaiga o vailaʻau faʻamaʻi faʻamaʻi faʻamaʻi lautele-alaala. E mafai ona faʻaaogaina mo togafitiga ma le puipuia o schistosomiasis, cysticercosis, paragonimiasis, faʻamaʻi hydatid, fasciolopsiasis, faʻamaʻi hydatid, ma faʻamaʻi anufe.
E mafai foʻi ona faʻaaogaina e avea ma vailaʻau faʻamaʻi ma aoga i le togafitia o nematodes gastrointestinal manu. E mafai ona faʻafefiloi i le fafaga mo le faʻaogaina.
O le oloa o se ituaiga o vailaau anthelmintic aoga i le togafitia o Schistosoma japonicum, Schistosoma mansoni ma Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms ma cysticercosis. E i ai sona aafiaga malosi fa'amamate i luga o le tapeworm ma o lo'o sili ona lelei i le taimi nei i vaila'au fa'ama'i-schistosomiasis.
O se ituaiga o vailaʻau faʻamaʻi e masani ona faʻaaogaina mo le togafitia o le schistosomiasis. E mafai foi ona faʻaaogaina mo togafitiga Fahrenheit schistosomiasis, taeniasis, paragonimiasis, ma cysticercosis
