Fa'amatalaga Puupuu:
Numera CAS:1264-72-8
Fuafua mole:2(C52H98N16O13).5(H2SO4)
mamafa mole:2801.27
Fa'atonuga vaila'au:
| Fa'amatalaga Autu | |
| Igoa o oloa | Colistin sulfate |
| Vasega | Fafaga Vasega |
| Fa'aaliga | Pa'epa'e pe toetoe a pa'epa'e, pa'u hygroscopic |
| Su'ega | 99% |
| Ola fa'asa | 2 tausaga |
| afifiina | 20kg/carton 20kg/drum |
| Tulaga | Teu i le -20 ℃ mo le tausaga e tasi(O le pauta） |
Faʻamatalaga o oloa
Colistin o se cyclic cationic decapeptide e fesoʻotaʻi ma se faʻamaʻi gaʻo itu itu filifili, o loʻo aʻafia i se vaega o peptides antimicrobial siama faʻapipiʻi tutusa. Colistin sulfate ose polypeptide antibiotic lea e taofia ai siama kalama-negative e ala i le fusifusia i lipopolysaccharides ma phospholipids i totonu o le sela pito i fafo o siama gram-negative.
Colistin sulfate, e lauiloa foi o le colistin sulfate, Kerisiano (Colistin), Polymyxin E(Polymyxin E), antiphytin, paʻepaʻe paʻepaʻe pe toetoe a paʻepaʻe, leai se manogi, tofo oona susu, faigofie ona solu i le vai, soluble i le methanol, ethanol, toetoe lava a le mafai ona solu i totonu. acetone, eter, free alkali solu teisi i le vai. Stable i le PH3-7.5 laina. O le Mycolistin sulfate e gaosia e le Bacillus polymyxoides, lea e malosi lona aafiaga antibacterial i siama gram-negative. E faʻaaogaina e togafitia ai faʻamaʻi o le intestinal e mafua mai i siama gram-negative, ma e faʻaaogaina e fai ma meaʻai faʻaopoopo ma faʻaalia le tuputupu aʻe o le aʻafiaga. O le tuʻufaʻatasiga o le sulfadiazine aafiaga e sili atu.
Galuega ole oloa
Colistin sulfate granules faʻaleleia atili i le mautu o le malosi i meaʻai ma faʻaalia le maualuga o le solubility e ui lava ina latou gaosia e aunoa ma le faʻaaogaina o soʻo se tau taugata poʻo meafaigaluega faʻapitoa. Aemaise lava, colistin sulfate granules e aofia ai le colistin sulfate ma e iai le lautele o le 150 i le 1500m, o se vaega faʻapitoa o le 40 i le 500 cm2/g, o le taimi susu o le 5 minute poʻo lalo ifo ma le susu o le 10% poʻo lalo ifo.
Pharmacodynamics
Colistin o se vailaʻau faʻamaʻi polymyxin. Polymyxins o cationic polypeptides e faʻalavelaveina le sela sela siama e ala i se masini fufulu. Faatasi ai ma le atinaʻeina o vailaʻau faʻaleagaina, e pei o penicillins lautele ma cephalosporins, o le faʻaaogaina o le polymyxin matua na matua lafoaia, sei vagana ai le togafitiga o faʻamaʻi pipisi o le pulmonary multidrug i tagata mamaʻi e maua i le cystic fibrosis.
