Fa'amatalaga Puupuu:
Numera CAS:24729-96-2
fua mole:C18H34ClN2O8PS
mamafa mole:504.96
Fa'atonuga vaila'au:
| Fa'amatalaga Autu | |
| Igoa o oloa | Clindamycin Phosphate |
| Vasega | Vasega Pharma |
| Fa'aaliga | pa'epa'e pa'epa'e |
| Su'ega | 95% |
| Ola fa'asa | 2 tausaga |
| afifiina | 25kg/tapa |
| Tulaga | Stable, ae malu teu oloa. E le fetaui ma vailaʻau faʻamaʻi malosi, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, vitamini sodium vaega B. |
Fa'amatalaga
Clindamycin phosphate o se vai-soluble ester o le semisynthetic antibiotic gaosia e se 7 (S) -chloro-sui o le 7 (R) -hydroxyl vaega o le matua antibiotic, lincomycin. O se mea e maua mai i le lincomycin (se lincosamide). O lo'o i ai le gaioiga fa'ama'i fa'asaga ia Gram-positive aerobes ma le tele o anaerobicbacteria. Ose vaila'au fa'aonaponei e fa'aaogaina i le togafitia o fa'ama'i pipisi. E ono aofia ai fa'ama'i pipisi o le manava, septicaemia, peritonitis ma fa'ama'i ponaivi. E fa'aaogaina fo'i e togafitia ai le pa'u feololo i le matuiā.
Fa'aoga
Clindamycin phosphate e faʻaaogaina i luga ole naʻo pe faʻatasi ma le benzoyl peroxide ile togafitiga ole inflammatory acne vulgaris. I le fuaina o faʻamanuiaga faʻapitoa o le clindamycin topical, e tatau ona mafaufauina le ono aʻafia ai o aʻafiaga ogaoga GI e fesoʻotaʻi ma le vailaʻau. Ole togafitiga ole acne vulgaris e tatau ona fa'apitoa ma fa'asolo soo ile fa'atatau ile ituaiga o manu'a e fa'ateleina ma le tali atu ile togafitiga. O vaila'au fa'ama'i fa'aonaponei, e aofia ai le clindamycin, e masani lava ona aoga i le togafitia o fa'ama'i mama'i ma feololo. Ae ui i lea, o le fa'aogaina o vaila'au fa'ama'i e pei o le monotherapy e mafai ona o'o atu ai i siama fa'ama'i; O lenei tete'e e feso'ota'i ma le fa'aitiitia o le aoga o le falema'i. O le clindamycin autu e sili ona aoga pe a fa'aaogaina i le benzoyl peroxide po'o le retinoids autu. O faʻaiʻuga o suʻesuʻega faʻapitoa e faʻaalia ai o togafitiga tuʻufaʻatasia e maua ai le faʻaitiitia o le aofaʻi o manuʻa e 50-70%.
Clindamycin 2-phosphate o se masima o le clincamycin, o se lincosamide semi-synthetic. O le masima e saunia e ala i le filifilia o le phosphorylation o le 2-hydroxy moiety o le suka o le clindamycin. O le fa'aofiina o le phosphate e maua ai le fa'aleleia atili o le solubility mo fa'ama'i tui. E pei o isi tagata o le aiga lincosamide, o le clindamycin 2-phosphate o se vailaʻau faʻamaʻi lautele ma gaioiga e faasaga i siama anaerobic ma protozoans. O le Clindamycin e galue e ala i le fusifusia i le 23S ribosomal subunit, poloka le faʻaogaina o porotini.
