Cefoperazone sodium + sulbactam sodium

Fa'amatalaga:
Cefoperazone sodium + sulbactam sodium (1: 1/2: 1) ose faʻamalosi matua, β-lactamase inhibitor na faʻalauiloaina talu ai nei o se oloa tuʻufaʻatasia 1: 1 ma le cefoperazone. E pei o le clavulanic acid, o le sui muamua o lenei ituaiga e faʻafeiloaʻi, sulbactam faʻaleleia le aoga o vailaʻau faʻamaʻi β-lactam e faʻasaga i faʻamaʻi.
Fa'aoga:
O se fa'ainitaneti β-lactamase semi-synthetic. E faʻaaogaina faʻatasi ma vailaʻau β-lactam e fai ma antibacterial.
Cefoperazone sodium masima o se cephalosporin antibiotic mo le taofia o le rMrp2-mediated [3H] E217βG uptake ma le IC50 o le 199 μM. Manulauti: Antibacterial Cefoperazone ose vaila'au fa'ama'i, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic mo le fa'aogaina o le toto po'o le intramuscular administration. A maeʻa le faʻaogaina o le 2 g o le Cefoperazone, o le maualuga o le serum na amata mai le 202μg / mL i le 375 μg / mL e faʻatatau i le vaitaimi o le faʻaaogaina o fualaau faasaina. A maeʻa le tui intramuscular o le 2 g o le Cefoperazone, o le maualuga maualuga o le serum maualuga o le 111 μg / mL ile 1.5 itula. I le 12 itula pe a uma le tui, o lona uiga o le maualuga o le serum o loʻo 2 i le 4 μg/mL. O le Cefoperazone e 90% e fusifusia i polotini serum.