Fa'amatalaga Puupuu:
Numera CAS:472-15-1
fua mole:C30H48O3
mamafa mole: 456.71
Fa'atonuga vaila'au:
| Fa'amatalaga Autu | |
| Igoa o oloa | Betulinic acid |
| Vasega | Vasega Pharma |
| Fa'aaliga | Pa'epa'e pe pa'epa'e |
| Su'ega | 98% |
| Ola fa'asa | 2 tausaga |
| afifiina | 25kg/tapa |
| Tulaga | Stable, ae malu teu oloa. E le fetaui ma vailaʻau faʻamaʻi malosi, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, vitamini sodium vaega B. |
Fa'amatalaga
Betulinic acid (472-15-1) ose Lupane triterpenoid natura mai le laau birch pa'epa'e (Betula pubescens). Fa'aoso apoptosis i le tele o laina sela.1 Fa'aoso mitochondrial permeability suiga pore matala.2 ?E fai ma chemosensitizer mo togafitiga fa'ama'i fa'ama'i kanesa i chemoresistant colon cancer cell lines.3 Cell permeable.
Fa'aoga
Betulinic Acid o se natura pentacyclic triterpenoid. Betulinic Acid o lo'o fa'aalia ai le anti-inflammatory ma le anti-HIV. Betulinic Acid e fa'aosoina fa'aoso apoptosis i sela tumo e ala i le fa'agaoioia sa'o o le ala mitochondrial o apoptosis e ala i le p53- ma le CD95-tutoatasi masini. Betulinic Acid o loʻo faʻaalia foi le TGR5 agonist gaioiga.
Betulinic acid (BetA) ua faʻaaogaina:
1.ia su'esu'e ona a'afiaga o se vaila'au fa'ama'i e fa'asaga i fa'ama'i Dengue (DENV).
2.e pei o se sterol faatonutonu elemene-saisai porotini (SREBP) inhibitor e taofiofia le lipid metabolism ma proliferation o sela manino sela fatu fatu (ccRCC) sela.
3.e pei o se togafitiga e suʻe ai ana mea e puipuia ai le pumo mo le olaola ma le apoptotic cell death assays i le tele o faʻataʻitaʻiga myeloma.
Su'esu'ega mo le kanesa
O lenei tuufaatasiga o se pentacyclic triterpene maua mai Betula ma Zizyphus ituaiga, lea e faʻaalia ai le cytotoxicity filifilia e faasaga i sela melanoma tagata (Shoeb2006). E faʻatupuina ituaiga okesene reactive, faʻagaoioia MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates le gaoioiga o le aminopeptidase-N, ma faapea ona inducesapoptosis i sela kanesa (Desai et al. 2008; Fulda 2008).
Gaioiga Fa'aola
Triterpenoid fa'anatura e fa'aalia ai le anti-HIV ma le antitumor. Faʻaosoina le gaosiga o meaola okesene reactive (ROS) ma faʻagaoioia le NF-κ B. Faʻaalia le gaioiga agonist TRG5 (EC 50 = 1.04 μ M).
Biochem/physiol Gaioiga
Betulinic acid, o se pentacyclic triterpene, e faʻaosoina faʻaosoina apoptosis i sela tumo e ala i le faʻagaoioia saʻo o le ala mitochondrial o apoptosis e ala i le p53- ma le CD95-tutoatasi masini.
